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3T3-L1 preadipocytes transfected with perilipin A stored 6- to 30-fold more TAG than control 3T3-L1 cells, resulting from a 5-fold reduction in the rate of lipolysis (15)

Adipocyte specific deletion of PNPLA2 also decreases lipids in serum and improves hepatic insulin sensitivity through decreased TAG accumulation, immune cell infiltration and inflammation in the liver (187)

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